5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity.

Product information

CAS Number: 191592-09-3

Molecular Weight: 400.49

Formula: C22H29FN4O2

Chemical Name: 5-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-8-hydroxy-1-methyl-1H,4H,5H,6H,7H,8H-pyrrolo[3,2-c]azepin-4-one

Smiles: CN1C=CC2C(=O)N(CCCN3CCN(CC3)C3C=CC(F)=CC=3)CCC(O)C1=2

InChiKey: KBZUFSZQLVRGPR-UHFFFAOYSA-N

InChi: InChI=1S/C22H29FN4O2/c1-24-11-7-19-21(24)20(28)8-12-27(22(19)29)10-2-9-25-13-15-26(16-14-25)18-5-3-17(23)4-6-18/h3-7,11,20,28H,2,8-10,12-16H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

5-HT2 antagonist 1 shows 45%, 88%, 93% inhibition of 10 μM erotonin-induced contraction at 10 nM, 100 nM, 1000 nM, respectively, in guinea pig mesentcric artery. 5-HT2 antagonist 1 causes 1% and 10% inhibition of 10 μM norepinephrine-induced contraction at 10 and 100 nM, respectively, in guinea pig aorta.

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